NFAT2-HDAC1 signaling contributes to the malignant phenotype of glioblastoma.

ABSTRACT:

Background

Deregulation of the nuclear factor of activated T cell (NFAT) pathway has been reported in several human cancers. Particularly, NFAT2 is involved in the malignant transformation of tumor cells and is identified as an oncogene. However, the role of NFAT2 in glioblastoma (GBM) is largely unknown.

Methods

The expression and prognostic value of NFAT2 were examined in the databases of the Repository of Molecular Brain Neoplasia Data and The Cancer Genome Atlas (TCGA) and clinical samples. The functional effects of silencing or overexpression of NFAT2 were evaluated in glioma stem cell (GSC) viability, invasion, and self-renewal in vitro and in tumorigenicity in vivo. The downstream target of NFAT2 was investigated.

Results

High NFAT2 expression was significantly

SUBMITTER: Song Y 

PROVIDER: S-EPMC6954451 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature