Large-scale comparative assessment of computational predictors for lysine post-translational modification sites.

ABSTRACT: Lysine post-translational modifications (PTMs) play a crucial role in regulating diverse functions and biological processes of proteins. However, because of the large volumes of sequencing data generated from genome-sequencing projects, systematic identification of different types of lysine PTM substrates and PTM sites in the entire proteome remains a major challenge. In recent years, a number of computational methods for lysine PTM identification have been developed. These methods show high diversity in their core algorithms, features extracted and feature selection techniques and evaluation strategies. There is therefore an urgent need to revisit these methods and summarize their methodologies, to improve and further develop computational techniques to identify and characterize lysine PT

SUBMITTER: Chen Z 

PROVIDER: S-EPMC6954452 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature