Dose-Dependent Growth Delay of Breast Cancer Xenografts in the Bone Marrow of Mice Treated with ²²³Ra: The Role of Bystander Effects and Their Potential for Therapy.

ABSTRACT: The role of radiation-induced bystander effects in radiation therapy remains unclear. With renewed interest in therapy with α-particle emitters, and their potential for sterilizing disseminated tumor cells (DTCs), it is critical to determine the contribution of bystander effects to the overall response so they can be leveraged for maximum clinical benefit. Methods: Female Foxn1_nu athymic nude mice were administered 0, 50, or 600 kBq/kg ²²³RaCl₂ to create bystander conditions. At 24 hours after administration, MDA-MB-231 or MCF-7 human breast cancer cells expressing luciferase were injected into the tibial marrow compartment. Tumor burden was tracked weekly via bioluminescence. Results: The MDA-MB-231 xenografts were observed to have a 1

SUBMITTER: Leung CN 

PROVIDER: S-EPMC6954456 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature