¹⁸F-FDG PET Dissemination Features in Diffuse Large B-Cell Lymphoma Are Predictive of Outcome.

ABSTRACT: We assessed the predictive value of new radiomic features characterizing lesion dissemination in baseline ¹⁸F-FDG PET and tested whether combining them with baseline metabolic tumor volume (MTV) could improve prediction of progression-free survival (PFS) and overall survival (OS) in diffuse large B-cell lymphoma (DLBCL) patients. Methods: From the LNH073B trial (NCT00498043), patients with advanced-stage DLCBL and ¹⁸F-FDG PET/CT images available for review were selected. MTV and several radiomic features, including the distance between the 2 lesions that were farthest apart (Dmax_patient), were calculated. Receiver-operating-characteristic analysis was used to determine the optimal cutoff for quantitative variables, and Kaplan-Meier survival analyses

SUBMITTER: Cottereau AS 

PROVIDER: S-EPMC6954460 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature