PET-Based Human Dosimetry of ⁶⁸Ga-NODAGA-Exendin-4, a Tracer for β-Cell Imaging.

ABSTRACT: ⁶⁸Ga-NODAGA-exendin-4 is a promising tracer for β-cell imaging using PET/CT. Possible applications include preoperative visualization of insulinomas and discrimination between focal and diffuse forms of congenital hyperinsulinism. There is also a significant role for this tracer in extending our knowledge on the role of β-cell mass in the pathophysiology of type 1 and type 2 diabetes by enabling noninvasive quantification of tracer uptake as a measure for β-cell mass. Calculating radiation doses from this tracer is important to assess its safety for use in patients (including young children) with benign diseases and healthy individuals. Methods: Six patients with hyperinsulinemic hypoglycemia were included. After intravenous injection of 100 MBq of the tracer, 4 successiv

SUBMITTER: Boss M 

PROVIDER: S-EPMC6954461 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature