Prospective Evaluation of PSMA-Targeted ¹⁸F-DCFPyL PET/CT in Men with Biochemical Failure After Radical Prostatectomy for Prostate Cancer.

ABSTRACT: Our purpose is to provide the results of a prospective study evaluating prostate-specific membrane antigen-targeted ¹⁸F-DCFPyL (2-(3-{1-carboxy-5-[(6-¹⁸F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid) PET/CT in patients with biochemical failure after radical prostatectomy for prostate cancer (PCa). Methods: Thirty-one patients with postprostatectomy serum prostate-specific antigen (PSA) levels of at least 0.2 ng/mL and negative conventional imaging results were enrolled in this study and imaged with ¹⁸F-DCFPyL PET/CT. A consensus central review identified foci of radiotracer uptake consistent with sites of PCa. Descriptive statistics were used. Results: Twenty-one patients (67.7%) had at least 1 finding on ¹⁸F

SUBMITTER: Rowe SP 

PROVIDER: S-EPMC6954467 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature