Construction of asthma related competing endogenous RNA network revealed novel long non-coding RNAs and potential new drugs.

ABSTRACT: BACKGROUND:Asthma is a heterogeneous disease characterized by chronic airway inflammation. Long non-coding RNA can act as competing endogenous RNA to mRNA, and play significant role in many diseases. However, there is little known about the profiles of long non-coding RNA and the long non-coding RNA related competing endogenous RNA network in asthma. In current study, we aimed to explore the long non-coding RNA-microRNA-mRNA competing endogenous RNA network in asthma and their potential implications for therapy and prognosis. METHODS:Asthma-related gene expression profiles were downloaded from the Gene Expression Omnibus database, re-annotated with these genes and identified for asthma-associated differentially expressed mRNAs and long non-coding RNAs. The long non-coding RNA-miRNA interac

SUBMITTER: Liao Y 

PROVIDER: S-EPMC6954528 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature