RTNduals: an R/Bioconductor package for analysis of co-regulation and inference of dual regulons.

ABSTRACT:

Motivation

Transcription factors (TFs) are key regulators of gene expression, and can activate or repress multiple target genes, forming regulatory units, or regulons. Understanding downstream effects of these regulators includes evaluating how TFs cooperate or compete within regulatory networks. Here we present RTNduals, an R/Bioconductor package that implements a general method for analyzing pairs of regulons.

Results

RTNduals identifies a dual regulon when the number of targets shared between a pair of regulators is statistically significant. The package extends the RTN (Reconstruction of Transcriptional Networks) package, and uses RTN transcriptional networks to identify significant co-regulatory associations between regulons. The Supplementary Information reports two ca

SUBMITTER: Chagas VS 

PROVIDER: S-EPMC6954650 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature