Quantification of the influence of drugs on zebrafish larvae swimming kinematics and energetics.

ABSTRACT: The use of zebrafish larvae has aroused wide interest in the medical field for its potential role in the development of new therapies. The larvae grow extremely quickly and the embryos are nearly transparent which allows easy examination of its internal structures using fluorescent imaging techniques. Medical treatment of zebrafish larvae can directly influence its swimming behaviours. These behaviour changes are related to functional changes of central nervous system and transformations of the zebrafish body such as muscle mechanical power and force variation, which cannot be measured directly by pure experiment observation. To quantify the influence of drugs on zebrafish larvae swimming behaviours and energetics, we have developed a novel methodology to exploit intravital changes based o

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC6954687 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature