Apathy as a behavioural marker of cognitive impairment in Parkinson's disease: a longitudinal analysis.

ABSTRACT:

Background

Understanding the longitudinal course of non-motor symptoms, and finding markers to predict cognitive decline in Parkinson's disease (PD), are priorities. Previous work has demonstrated that apathy is one of the only behavioural symptoms that differentiates people with PD and intact cognition from those with mild cognitive impairment (MCI-PD). Other psychiatric symptoms emerge as dementia in PD develops.

Objective

We explored statistical models of longitudinal change to detect apathy as a behavioural predictor of cognitive decline in PD.

Methods

We followed 104 people with PD intermittently over 2 years, undertaking a variety of motor, behavioural and cognitive measures. We applied a linear mixed effects model to explore behavioural factors associated with

SUBMITTER: Martin GP 

PROVIDER: S-EPMC6954881 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature