Preparation and evaluation of microfluidic magnetic alginate microparticles for magnetically templated hydrogels.

ABSTRACT: Our aim is to develop a hydrogel-based scaffold containing porous microchannels that mimic complex tissue microarchitecture and provide physical cues to guide cell growth for scalable, cost-effective tissue repair. These hydrogels are patterned through the novel process of magnetic templating where magnetic alginate microparticles (MAMs) are dispersed in a hydrogel precursor and aligned in a magnetic field before hydrogel crosslinking and subsequent MAM degradation, leaving behind an aligned, porous architecture. Here, a protocol for fabricating uniform MAMs using microfluidics was developed for improved reproducibility and tunability of templated microarchitecture. Through iron quantification, we find that this approach allows control over magnetic iron oxide loading of the MAMs. Using Br

SUBMITTER: Singh I 

PROVIDER: S-EPMC6955151 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature