DeepRiPP integrates multiomics data to automate discovery of novel ribosomally synthesized natural products.

ABSTRACT: Microbial natural products represent a rich resource of evolved chemistry that forms the basis for the majority of pharmacotherapeutics. Ribosomally synthesized and posttranslationally modified peptides (RiPPs) are a particularly interesting class of natural products noted for their unique mode of biosynthesis and biological activities. Analyses of sequenced microbial genomes have revealed an enormous number of biosynthetic loci encoding RiPPs but whose products remain cryptic. In parallel, analyses of bacterial metabolomes typically assign chemical structures to only a minority of detected metabolites. Aligning these 2 disparate sources of data could provide a comprehensive strategy for natural product discovery. Here we present DeepRiPP, an integrated genomic and metabolomic platform tha

SUBMITTER: Merwin NJ 

PROVIDER: S-EPMC6955231 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature