Differential Expression of Immune Checkpoint Molecules on CD8⁺ T Cells Specific for Immunodominant and Subdominant Herpes Simplex Virus 1 Epitopes.

ABSTRACT: Herpes simplex virus 1 (HSV-1) causes a lifelong infection of neurons that innervate barrier sites like the skin and mucosal surfaces like the eye. After primary infection of the cornea, the virus enters latency within the trigeminal ganglion (TG), from which it can reactivate throughout the life of the host. Viral latency is maintained, in part, by virus-specific CD8⁺ T cells that nonlethally interact with infected neurons. When CD8⁺ T cell responses are inhibited, HSV-1 can reactivate, and these recurrent reactivation events can lead to blinding scarring of the cornea. In the C57BL/6 mouse, CD8⁺ T cells specific for the immunodominant epitope from glycoprotein B maintain functionality throughout latency, while CD8⁺ T cells specific for subdomin

SUBMITTER: Carroll KL 

PROVIDER: S-EPMC6955272 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature