Light-driven carbon-carbon bond formation via CO₂ reduction catalyzed by complexes of CdS nanorods and a 2-oxoacid oxidoreductase.

ABSTRACT: Redox enzymes are capable of catalyzing a vast array of useful reactions, but they require redox partners that donate or accept electrons. Semiconductor nanocrystals provide a mechanism to convert absorbed photon energy into redox equivalents for enzyme catalysis. Here, we describe a system for photochemical carbon-carbon bond formation to make 2-oxoglutarate by coupling CO₂ with a succinyl group. Photoexcited electrons from cadmium sulfide nanorods (CdS NRs) transfer to 2-oxoglutarate:ferredoxin oxidoreductase from Magnetococcus marinus MC-1 (MmOGOR), which catalyzes a carbon-carbon bond formation reaction. We thereby decouple MmOGOR from its native role in the reductive tricarboxylic acid cycle and drive it directly with light. We examine the dependence of 2-oxoglutarat

SUBMITTER: Hamby H 

PROVIDER: S-EPMC6955356 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature