Abortive herpes simplex virus infection of nonneuronal cells results in quiescent viral genomes that can reactivate.

ABSTRACT: Abortive viral infections are usually studied in populations of susceptible but nonpermissive cells. Single-cell studies of viral infections have demonstrated that even in susceptible and permissive cell populations, abortive infections can be detected in subpopulations of the infected cells. We have previously identified abortive infections in HeLa cells infected with herpes simplex virus 1 (HSV-1) at high multiplicity of infection (MOI). Here, we tested 4 additional human-derived nonneuronal cell lines (cancerous or immortalized) and found significant subpopulations that remain abortive. To characterize these abortive cells, we recovered cell populations that survived infection with HSV-1 at high MOI. The surviving cells retained proliferative potential and the ability to be reinfected.

SUBMITTER: Cohen EM 

PROVIDER: S-EPMC6955376 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature