Ontology highlight
ABSTRACT:
SUBMITTER: Anton OM
PROVIDER: S-EPMC6955382 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Anton Olga M OM Peterson Mary E ME Hollander Michael J MJ Dorward David W DW Arora Gunjan G Traba Javier J Rajagopalan Sumati S Snapp Erik L EL Garcia K Christopher KC Waldmann Thomas A TA Long Eric O EO
Proceedings of the National Academy of Sciences of the United States of America 20191223 1
Interleukin 15 (IL-15) is an essential cytokine for the survival and proliferation of natural killer (NK) cells. IL-15 activates signaling by the β and common γ (γ<sub>c</sub>) chain heterodimer of the IL-2 receptor through <i>trans</i>-presentation by cells expressing IL-15 bound to the α chain of the IL-15 receptor (IL-15Rα). We show here that membrane-associated IL-15Rα-IL-15 complexes are transferred from presenting cells to NK cells through <i>trans</i>-endocytosis and contribute to the pho ...[more]