Longitudinal exposure of English primary care patients to pharmacogenomic drugs: An analysis to inform design of pre-emptive pharmacogenomic testing.

ABSTRACT:

Aims

To investigate the longitudinal exposure of English primary care patients to pharmacogenomic drugs to inform design of pre-emptive testing.

Methods

Sixty-three drugs were identified with dosing guidelines based on variants of 19 pharmacogenes in the Pharmacogenomics Knowledgebase on 01 September 2018. Prescribing of these pharmacogenomic drugs between 1993 and 2017 was summarised for a sample of 648 141 English patients aged 50-99 years on 01 January 2013, registered with Clinical Practice Research Datalink practices during 2011-12. Exposure of patients to pharmacogenomic drugs retrospectively (2, 10, 20 y) and prospectively (5 y) was described.

Results

During 2011-12, 58% of patients were prescribed at least 1 pharmacogenomic drug, increasing to 80% over the pre

SUBMITTER: Kimpton JE 

PROVIDER: S-EPMC6955399 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature