Physiologically based pharmacokinetic evaluation of cefuroxime in perioperative antibiotic prophylaxis.

ABSTRACT:

Aims

Adequate plasma concentrations of antibiotics during surgery are essential for the prevention of surgical site infections. We examined the pharmacokinetics of 1.5 g cefuroxime administered during induction of anaesthesia with follow-up doses every 2.5 hours until the end of surgery. We built a physiologically based pharmacokinetic model with the aim to ensure adequate antibiotic plasma concentrations in a heterogeneous population.

Methods

A physiologically based pharmacokinetic model (PK-Sim^® /MoBi^® ) was developed to investigate unbound plasma concentrations of cefuroxime. Blood samples from 25 thoracic surgical patients were analysed with high-performance liquid chromatography. To evaluate optimized dosing regimens, physiologically based pharmaco

SUBMITTER: Rimmler C 

PROVIDER: S-EPMC6955413 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature