Postoperative intravenous parecoxib sodium followed by oral celecoxib post total knee arthroplasty in osteoarthritis patients (PIPFORCE): a multicentre, double-blind, randomised, placebo-controlled trial.

ABSTRACT:

Objectives

To evaluate the morphine-sparing effects of the sequential treatment versus placebo in subjects undergoing total knee arthroplasty (TKA), the effects on pain relief, inflammation control and functional rehabilitation after TKA and safety.

Design

Double-blind, pragmatic, randomised, placebo-controlled trial.

Setting

Four tertiary hospitals in China.

Participants

246 consecutive patients who underwent elective unilateral TKA because of osteoarthritis (OA).

Interventions

Patients were randomised 1:1 to the parecoxib/celecoxib group or the control group. The patients in the parecoxib/celecoxib group were supplied sequential treatment with intravenous parecoxib 40 mg (every 12 hours) for the first 3 days after surgery, followed by oral celecoxib 20

SUBMITTER: Zhuang Q 

PROVIDER: S-EPMC6955469 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature