Exploring failure of antimicrobial prophylaxis and pre-emptive therapy for transplant recipients: a systematic review.

ABSTRACT:

Objectives

Infections remain a threat for solid organ and stem cell transplant recipients. Antimicrobial prophylaxis and pre-emptive therapy have improved survival of these patients; however, the failure rates of prophylaxis are not negligible. The aim of this systematic review is to explore the reasons behind failure of antimicrobial prophylaxis and pre-emptive therapy.

Setting

This systematic review included prospective randomised controlled trials and prospective single-arm studies.

Participants

The studies included were on prophylaxis and pre-emptive therapy of opportunistic infections in transplant recipients. Studies were included from databases MEDLINE, CENTRAL and Embase published until October first 2018.

Primary and secondary outcome measures

Primary

SUBMITTER: Martson AG 

PROVIDER: S-EPMC6955515 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature