Lithium for Fracture Treatment (LiFT): a double-blind randomised control trial protocol.

ABSTRACT:

Introduction

Fracture healing can fail in up to 10% of cases despite appropriate treatment. While lithium has been the standard treatment for bipolar disorder, it may also have a significant impact to increase bone healing in patients with long bone fractures. To translate this knowledge into clinical practice, a randomised clinical trial (RCT) is proposed.

Methods and analysis

A multicentre double blind, placebo-controlled RCT is proposed to evaluate the efficacy of lithium to increase the rate and predictability of long bone fracture healing in healthy adults compared to lactose placebo treatment. 160 healthy individuals from 18 to 55 years of age presenting with shaft fractures of the femur, tibia/fibula, humerus or clavicle will be eligible. Fractures will be randomised

SUBMITTER: Nam D 

PROVIDER: S-EPMC6955565 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature