A Pathway-Based Genomic Approach to Identify Medications: Application to Alcohol Use Disorder.

ABSTRACT: Chronic, excessive alcohol use alters brain gene expression patterns, which could be important for initiating, maintaining, or progressing the addicted state. It has been proposed that pharmaceuticals with opposing effects on gene expression could treat alcohol use disorder (AUD). Computational strategies comparing gene expression signatures of disease to those of pharmaceuticals show promise for nominating novel treatments. We reasoned that it may be sufficient for a treatment to target the biological pathway rather than lists of individual genes perturbed by AUD. We analyzed published and unpublished transcriptomic data using gene set enrichment of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways to identify biological pathways disrupted in AUD brain and by compounds in the Librar

SUBMITTER: Ferguson LB 

PROVIDER: S-EPMC6956180 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature