Complement C3 overexpression activates JAK2/STAT3 pathway and correlates with gastric cancer progression.

ABSTRACT:

Background

Localized C3 deposition is a well-known factor of inflammation. However, its role in oncoprogression of gastric cancer (GC) remains obscured. This study aims to explore the prognostic value of C3 deposition and to elucidate the mechanism of C3-related oncoprogression for GC.

Methods

From August to December 2013, 106 GC patients were prospectively included. The regional expression of C3 and other effectors in gastric tissues were detected by WB, IHC, qRT-PCR and other tests. The correlation of localized C3 deposition and oncologic outcomes was determined by 5-year survival significance. Human GC and normal epithelial cell lines were employed to detect a relationship between C3 and STAT3 signaling pathway in vitro experiments.

Results

C3 and C3a expression we

SUBMITTER: Yuan K 

PROVIDER: S-EPMC6956509 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature