Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice.

ABSTRACT: Caloric restriction has been associated with increased life span and reduced aging-related disorders and reduces fibrosis in several diseases. Fibrosis is characterized by deposition of excess fibrous material in tissues and organs and is caused by aging, chronic stress, injury, or disease. Myofibroblasts are fibroblast-like cells that secrete high levels of extracellular matrix proteins, resulting in fibrosis. Histological studies have identified many-fold increases of myofibroblasts in aged organs where myofibroblasts are constantly generated from resident tissue fibroblasts and other cell types. However, it remains unclear how aging increases the generation of myofibroblasts. Here, using mouse models and biochemical assays, we show that sirtuin 6 (SIRT6) deficiency plays a major role in

SUBMITTER: Maity S 

PROVIDER: S-EPMC6956532 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature