A global analysis of function and conservation of catalytic residues in enzymes.

ABSTRACT: The catalytic residues of an enzyme comprise the amino acids located in the active center responsible for accelerating the enzyme-catalyzed reaction. These residues lower the activation energy of reactions by performing several catalytic functions. Decades of enzymology research has established general themes regarding the roles of specific residues in these catalytic reactions, but it has been more difficult to explore these roles in a more systematic way. Here, we review the data on the catalytic residues of 648 enzymes, as annotated in the Mechanism and Catalytic Site Atlas (M-CSA), and compare our results with those in previous studies. We structured this analysis around three key properties of the catalytic residues: amino acid type, catalytic function, and sequence conservation in ho

SUBMITTER: Ribeiro AJM 

PROVIDER: S-EPMC6956550 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature