Involvement of collagen XVII in pluripotency gene expression and metabolic reprogramming of lung cancer stem cells.

ABSTRACT:

Background

Recent advancements in cancer biology field suggest that glucose metabolism is a potential target for cancer treatment. However, little if anything is known about the metabolic profile of cancer stem cells (CSCs) and the related underlying mechanisms.

Methods

The metabolic phenotype in lung CSC was first investigated. The role of collagen XVII, a putative stem cell or CSC candidate marker, in regulating metabolic reprogramming in lung CSC was subsequently studied. Through screening the genes involved in glycolysis, we identified the downstream targets of collagen XVII that were involved in metabolic reprogramming of lung CSCs. Collagen XVII and its downstream targets were then used to predict the prognosis of lung cancer patients.

Results

We showed that an

SUBMITTER: Hsu HS 

PROVIDER: S-EPMC6956558 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature