Association of VDR Gene Variant (rs1544410) with Type 2 Diabetes in a Pakistani Cohort.

ABSTRACT: The present study was designed to measure the mean values of body mass index (BMI), random blood sugar/ fast ing blood sugar (RBS/FBS) tests, and Hb A_1c and to investigate the role of a genetic variant rs1544410 in the VDR gene in a Pakistani cohort. For this purpose, a total of 917 samples including 469 diabetes mellitus type 2 (T2DM), 145 DM type 1 (T1DM), and 303 healthy control were collected. Out of the total sample set, 500 individuals (250 T2DM cases and 250 controls) were genotyped for rs1544410. It was found that 65 (26.0%) cases and 32 (12.8%) controls had homozygous AA, while 69 (27.6%) cases and 139 (55.6%) controls had heterozygous AG, and 116 (46.4%) cases and 79 (31.6%) controls had homozygous GG (χ² = 41.81, p = 0.0001). In addition, a si

SUBMITTER: Khan A 

PROVIDER: S-EPMC6956633 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature