In silico unravelling pathogen-host signaling cross-talks via pathogen mimicry and human protein-protein interaction networks.

ABSTRACT: Pathogen-host protein interactions are fundamental for pathogens to manipulate host signaling pathways and subvert host immune defense. For most pathogens, very few or no experimental studies have been conducted to investigate their signaling cross-talks with host. In this study, we propose a computational framework to validate the biological assumption that human protein-protein interaction (PPI) networks alone are sufficient to infer pathogen-host PPIs via pathogen functional mimicry. Pathogen functional mimicry assumes that a pathogen functionally mimics and substitutes host counterpart proteins in order for the pathogen to get involved in or hijack the host cellular processes. Through pathogen functional mimicry defined via gene ontology (GO) semantic similarity, we first use the known

SUBMITTER: Mei S 

PROVIDER: S-EPMC6956678 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature