Neuroprotectants attenuate hypobaric hypoxia-induced brain injuries in cynomolgus monkeys.

ABSTRACT: Hypobaric hypoxia (HH) exposure can cause serious brain injury as well as life-threatening cerebral edema in severe cases. Previous studies on the mechanisms of HH-induced brain injury have been conducted primarily using non-primate animal models that are genetically distant to humans, thus hindering the development of disease treatment. Here, we report that cynomolgus monkeys ( Macaca fascicularis) exposed to acute HH developed human-like HH syndrome involving severe brain injury and abnormal behavior. Transcriptome profiling of white blood cells and brain tissue from monkeys exposed to increasing altitude revealed the central role of the HIF-1 and other novel signaling pathways, such as the vitamin D receptor (VDR) signaling pathway, in co-regulating HH-induced inflammation

SUBMITTER: Zhang P 

PROVIDER: S-EPMC6956719 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature