Resolvin D1 promotes efferocytosis in aging by limiting senescent cell-induced MerTK cleavage.

ABSTRACT: Inflammation-resolution is mediated by the balance between specialized pro-resolving mediators (SPMs) like resolvin D1 (RvD1) and pro-inflammatory factors, like leukotriene B₄ (LTB₄). A key cellular process of inflammation-resolution is efferocytosis. Aging is associated with defective inflammation-resolution and the accumulation of pro-inflammatory senescent cells (SCs). Therefore, understanding mechanism(s) that underpin this impairment is a critical gap. Here, using a model of hind limb ischemia-reperfusion (I/R) remote lung injury, we present evidence that aging is associated with heightened inflammation, impaired SPM:LT ratio, defective efferocytosis, and a decrease in MerTK levels in injured lungs. Treatment with RvD1 mitigated I/R lung injury in aging, promoted

SUBMITTER: Rymut N 

PROVIDER: S-EPMC6956736 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature