Synthesis and applications of theranostic oligonucleotides carrying multiple fluorine atoms.

ABSTRACT: The use of various oligonucleotide (ON) syntheses and post-synthetic strategies for targeted chemical modification enables improving their efficacy as potent modulators of gene expression levels in eukaryotic cells. However, the search still continues for new approaches designed for increasing internalization, lysosomal escape, and tissue specific delivery of ON. In this review we emphasized all aspects related to the synthesis and properties of ON derivatives carrying multifluorinated (MF) groups. These MF groups have unique physico-chemical properties because of their simultaneous hydrophobicity and lipophobicity. Such unusual combination of properties results in the overall modification of ON mode of interaction with the cells and making multi-fluorination highly relevant to the goal of

SUBMITTER: Metelev VG 

PROVIDER: S-EPMC6956824 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature