Association of Metformin Initiation and Risk of Asthma Exacerbation. A Claims-based Cohort Study.

ABSTRACT: Rationale: Diabetes and metabolic syndrome have been associated with worsened asthma control. Metformin improves insulin resistance and metabolic function. Experimental studies suggest that metformin may improve pathologic features of asthma, but evidence of clinical benefit is limited.Objectives: To determine if treatment with metformin in a cohort of individuals with asthma and diabetes is associated with lower risk of asthma exacerbation.Methods: A 6-year retrospective cohort of individuals over age 18 with asthma and diabetes was assembled from a national administrative claims database. New users of metformin were matched to nonusers by propensity score on the basis of demographic, comorbidity, and medication-use characteristics. An exacerbation was defined as an a

SUBMITTER: Wu TD 

PROVIDER: S-EPMC6956833 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature