Quantitative ferumoxytol-enhanced MRI in pregnancy: A feasibility study in the nonhuman primate.

ABSTRACT:

Objectives

To assess the feasibility of ferumoxytol-enhanced MRI in pregnancy with a nonhuman primate model.

Materials and methods

In this prospective study, eleven pregnant rhesus macaques at day 98 ± 5 of gestation were divided into three groups, untreated control (UC) (n = 3), saline control (SC) (n = 4) and interleukin 1 beta (IL-1β) treated (IT) (n = 4), which were administered with either saline or IL-1β into the amniotic fluid. All animals were imaged at multiple time points before and after ferumoxytol administration (4 mg/kg). Longitudinal R2* and susceptibility of tissues were obtained using region-of-interest analysis and the longitudinal changes were assessed using linear mixed models and Student's t-test.

Results

In fetuses, a slope of 0.3 s^-

SUBMITTER: Zhu A 

PROVIDER: S-EPMC6956847 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature