Serum IGFBP-1 as a potential biomarker for diagnosis of early-stage upper gastrointestinal tumour.

ABSTRACT:

Background

Early detection would improve upper gastrointestinal cancer prognosis. We aimed to identify serum protein biomarker for the detection of early-stage upper gastrointestinal cancer.

Methods

We performed a three-tiered study including 2028 participants from three medical centres. First, we applied two different antibody arrays to screen candidate serum proteins that increased in 20 patients with oesophageal squamous cell carcinoma (ESCC) compared with 20 normal controls. We then evaluated the selected protein by enzyme-linked immunosorbent assay in 1064 participants including 731 upper gastrointestinal cancer patients (287 ESCCs, 237 oesophagogastric junction adenocarcinomas (EJAs), and 207 stomach cancers) and 333 normal controls. The diagnostic value of the selecte

SUBMITTER: Xu YW 

PROVIDER: S-EPMC6956950 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature