The General Anesthetic Isoflurane Bilaterally Modulates Neuronal Excitability.

ABSTRACT: Volatile anesthetics induce hyperactivity during induction while producing anesthesia at higher concentrations. They also bidirectionally modulate many neuronal functions. However, the neuronal mechanism is unclear. The effects of isoflurane on sodium channel currents were analyzed in acute mouse brain slices, including sodium leak (NALCN) currents and voltage-gated sodium channels (Na_v) currents. Isoflurane at sub-anesthetic concentrations increased the spontaneous firing rate of CA3 pyramidal neurons, whereas anesthetic concentrations of isoflurane decreased the firing rate. Isoflurane at sub-anesthetic concentrations enhanced NALCN conductance but minimally inhibited Na_v currents. Isoflurane at anesthetic concentrations depressed Na_v currents and action

SUBMITTER: Ou M 

PROVIDER: S-EPMC6956953 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature