Vascularization and biocompatibility of poly(ε-caprolactone) fiber mats for rotator cuff tear repair.

ABSTRACT: Rotator cuff tear is the most frequent tendon injury in the adult population. Despite current improvements in surgical techniques and the development of grafts, failure rates following tendon reconstruction remain high. New therapies, which aim to restore the topology and functionality of the interface between muscle, tendon and bone, are essentially required. One of the key factors for a successful incorporation of tissue engineered constructs is a rapid ingrowth of cells and tissues, which is dependent on a fast vascularization. The dorsal skinfold chamber model in female BALB/cJZtm mice allows the observation of microhemodynamic parameters in repeated measurements in vivo and therefore the description of the vascularization of different implant materials. In order to promote vasculariza

SUBMITTER: Gniesmer S 

PROVIDER: S-EPMC6957163 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature