Noninvasive Detection of Colorectal Carcinomas Using Serum Protein Biomarkers.

ABSTRACT:

Background

A major roadblock to reducing the mortality of colorectal cancer (CRC) is prompt detection and treatment, and a simple blood test is likely to have higher compliance than all of the current methods. The purpose of this report is to examine the utility of a mass spectrometry-based blood serum protein biomarker test for detection of CRC.

Materials and methods

Blood was drawn from individuals (n = 213) before colonoscopy or from patients with nonmetastatic CRC (n = 50) before surgery. Proteins were isolated from the serum of patients using targeted liquid chromatography-tandem mass spectrometry. We designed a machine-learning statistical model to assess these proteins.

Results

When considered individually, over 70% of the selected biomarkers showed significanc

SUBMITTER: Ivancic MM 

PROVIDER: S-EPMC6957232 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature