Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals.

ABSTRACT:

Background

The incidence of cardiovascular disease is higher in HIV-positive (HIV⁺) patients than it is in the average population, and combination antiretroviral therapy (cART) is a recognized risk factor for cardiovascular disease. However, the molecular mechanisms that link cART and cardiovascular disease are currently unknown. Our study explores the role of the activation of p90RSK, a reactive oxygen species-sensitive kinase, in engendering senescent phenotype in macrophages and accelerating atherogenesis in patients undergoing cART.

Methods

Peripheral whole blood from cART-treated HIV⁺ individuals and nontreated HIV-negative individuals was treated with H₂O₂ (200 µmol/L) for 4 minutes, and p90RSK activity in CD14⁺ mo

SUBMITTER: Singh MV 

PROVIDER: S-EPMC6957233 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature