Sustained successful peanut oral immunotherapy associated with low basophil activation and peanut-specific IgE.

ABSTRACT: BACKGROUND:Oral immunotherapy (OIT) can successfully desensitize many peanut-allergic subjects, but clinical tolerance diminishes over time on discontinuation, or low-dose maintenance, of peanut. Therefore, to improve the efficacy and sustainability of such therapy, we sought to identify biomarkers and clinical tools that can predict therapeutic outcomes and monitor treatment responses. OBJECTIVE:We evaluated whether basophil activation in whole blood, and plasma levels of peanut-specific immunoglobulins, are useful biomarkers for peanut OIT. METHODS:We longitudinally measured, before, during, and after OIT, basophil activation in whole blood ex vivo in response to peanut stimulation, and peanut-specific IgE (sIgE) and peanut-specific IgG₄ (sIgG₄), in a large, single-

SUBMITTER: Tsai M 

PROVIDER: S-EPMC6957313 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature