Slc26a6 is an apical membrane anion exchanger that drives HCO₃^--dependent fluid secretion in murine pancreatic acinar cells.

ABSTRACT: The nonselective anion exchanger Slc26a6, also known as putative anion transporter 1 and chloride/formate exchanger, is thought to play a major role in HCO3- transport in exocrine glands. In this study, Slc26a6 null mice were used to explore the function of Slc26a6 in the exocrine pancreas. Slc26a6 primarily localized to the apical membrane of pancreatic exocrine acinar cells. The volume of stimulated juice secretion by the ex vivo pancreas was significantly reduced ~35% in Slc26a6^-/- mice, but no changes occurred in the gross structure or gland weights of Slc26a6 null mice. The secretion of pancreatic juice by Slc26a6^+/+ mice was dependent on HCO3- while, in contrast, fluid secretion by Slc26a6^-/- mice was independent of

SUBMITTER: Munemasa T 

PROVIDER: S-EPMC6957380 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature