Association between adenovirus viral load and mortality in pediatric allo-HCT recipients: the multinational AdVance study.

ABSTRACT: This multivariable analysis from the AdVance multicenter observational study assessed adenovirus (AdV) viremia peak, duration, and overall AdV viral burden-measured as time-averaged area under the viremia curve over 16 weeks (AAUC_0-16)-as predictors of all-cause mortality in pediatric allo-HCT recipients with AdV viremia. In the 6 months following allo-HCT, 241 patients had AdV viremia ≥ 1000 copies/ml. Among these, 18% (43/241) died within 6 months of first AdV ≥ 1000 copies/ml. Measures of AdV viral peak, duration, and overall burden of infection consistently correlate with all-cause mortality. In multivariable analyses, controlling for lymphocyte recovery, patients with AdV AAUC_0-16 in the highest quartile had a hazard ratio of 11.1 versus the lowest quartile (conf

SUBMITTER: Zecca M 

PROVIDER: S-EPMC6957460 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature