Delayed ventilation assessment using fast dynamic hyperpolarised Xenon-129 magnetic resonance imaging.

ABSTRACT:

Objectives

To investigate the use of a fast dynamic hyperpolarised ¹²⁹Xe ventilation magnetic resonance imaging (DXeV-MRI) method for detecting and quantifying delayed ventilation in patients with chronic obstructive pulmonary disease (COPD).

Methods

Three male participants (age range 31-43) with healthy lungs and 15 patients (M/F = 12:3, age range = 48-73) with COPD (stages II-IV) underwent spirometry tests, quantitative chest computed tomography (QCT), and DXeV-MRI at 1.5-Tesla. Regional delayed ventilation was captured by measuring the temporal signal change in each lung region of interest (ROI) in comparison to that in the trachea. In addition to its qualitative assessment through visual inspection by a clinical radiologist, delayed ventilation was quantitativ

SUBMITTER: Chen M 

PROVIDER: S-EPMC6957546 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature