The Optimal Age of Vaccination Against Dengue with an Age-Dependent Biting Rate with Application to Brazil.

ABSTRACT: In this paper we introduce a single serotype transmission model, including an age-dependent mosquito biting rate, to find the optimal vaccination age against dengue in Brazil with Dengvaxia. The optimal vaccination age and minimal lifetime expected risk of hospitalisation are found by adapting a method due to Hethcote (Math Biosci 89:29-52). Any number and combination of the four dengue serotypes DENv1-4 is considered. Successful vaccination against a serotype corresponds to a silent infection. The effects of antibody-dependent enhancement (ADE) and permanent cross-immunity after two heterologous infections are studied. ADE is assumed to imply risk-free primary infections, while permanent cross-immunity implies risk-free tertiary and quaternary infections. Data from trials of Dengvaxia ind

SUBMITTER: Maier SB 

PROVIDER: S-EPMC6957571 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature