B cell ADAM17 controls T cell independent humoral immune responses through regulation of TACI and CD138.

ABSTRACT: ADAM17 is known to contribute to the immune system through its shedding of tumor necrosis factor alpha (TNF?). However, the role of ADAM17 in B cell biology is not well characterized. To determine whether B cell ADAM17 contributes to T cell-independent humoral immune responses, we crossed CD19 Cre transgenic mice with mice bearing a floxed allele of ADAM17 (ADAM17CD19). In this study, we show a B cell intrinsic role for ADAM17 in regulating marginal zone B cell (MZB) numbers in mice. Interestingly, we demonstrate that the loss of B cell ADAM17 results in reduced MZB numbers in the naïve state and after immunization with T-independent antigen, yet enhanced humoral immunity to T cell independent antigens. We additionally find elevated TACI and CD138 levels on plasma cells following immunization in ADAM17CD19 mice. Overall, these findings suggest that B cell ADAM17 may orchestrate T independent immune responses through both MZB numbers and plasma cell antibody production.

SUBMITTER: Lownik JC 

PROVIDER: S-EPMC6957701 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature