Variability in urinary neonicotinoid concentrations in single-spot and first-morning void and its association with oxidative stress markers.

ABSTRACT: Human exposure to neonicotinoid insecticides (hereafter "neonics") is a concern. Spot urine samples have been widely used in the assessment of exposure to neonics. Urinary concentrations, however, can vary greatly over time due to variable exposure, potentially leading to exposure misclassification. In this study, within- and between-individual variability of urinary concentrations of 13 neonics and their metabolites collected consecutively for up to 44 days from 19 individuals were examined. We also measured seven oxidative stress biomarkers (OSBs) in repeated urine samples to elucidate their relationship with neonic exposure by mixed regression models. Intraclass correlation coefficients (ICCs, a ratio of between-individual variance to total variance) were used to assess the reproducibil

SUBMITTER: Li AJ 

PROVIDER: S-EPMC6957733 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature