Unleashing shear: Role of intercellular traction and cellular moments in collective cell migration.

ABSTRACT: In the field of endothelial biology, the term "shear forces" is tied to the forces exerted by the flowing blood on the quiescent cells. But endothelial cells themselves also exert physical forces on their immediate and distant neighbors. Specific factors of such intrinsic mechanical signals most relevant to immediate neighbors include normal (F_n) and shear (F_s) components of intercellular tractions, and those factors most relevant to distant neighbors include contractile or dilatational (M_c) and shear (M_s) components of the moments of cytoskeletal forces. However, for cells within a monolayer, F_n, F_s, M_c, and M_s remain inaccessible to experimental evaluation. Here, we present an approach that enables qu

SUBMITTER: Patel NG 

PROVIDER: S-EPMC6957749 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature