Nitrite pharmacokinetics, safety and efficacy after experimental ventricular fibrillation cardiac arrest.

ABSTRACT:

Introduction

Besides therapeutic hypothermia or targeted temperature management no novel therapies have been developed to improve outcomes of patients after cardiac arrest (CA). Recent studies suggest that nitrite reduces neurological damage after asphyxial CA. Nitrite is also implicated as a new mediator of remote post conditioning produced by tourniquet inflation-deflation, which is under active investigation in CA. However, little is known about brain penetration or pharmacokinetics (PK). Therefore, to define the optimal use of this agent, studies on the PK of nitrite in experimental ventricular fibrillation (VF) are needed. We tested the hypothesis that nitrite administered after resuscitation from VF is detectable in cerebrospinal fluid (CSF), brain and other organ tissues, pr

SUBMITTER: Uray T 

PROVIDER: S-EPMC6957908 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature