Associations of miR-605 rs2043556 polymorphism with the susceptibility and overall survival of lung cancer in Chinese non-smoking females.

ABSTRACT: The effects of miR-605 rs2043556 single nucleotide polymorphism (SNP) on the risk and prognosis of lung cancer are unclear. This study investigated the relationships between miR-605 rs2043556 and the susceptibility and overall survival (OS) of lung cancer in Chinese non-smoking females. This hospital-based case-control study included 450 cases and 450 controls. Also, a prospective cohort study was carried out, and the patients were followed up until February 29th, 2016. There were 334 patients with prognostic information. Odds ratio and hazard ratio (HR) and their 95% confidence intervals (CIs) were calculated, respectively. In squamous cell carcinomas (SqCC) patients, homozygous GG genotype carriers had a 2.157-fold elevated risk of lung cancer compared with homozygous AA genotype carrier

SUBMITTER: Xu X 

PROVIDER: S-EPMC6957935 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature