Expression of oxytocin receptor in the rat superior cervical ganglion after myocardial infarction.

ABSTRACT: BACKGROUND:Myocardial infarction (MI) accompanied with abnormal sympathetic innervation, meanwhile, some studies have revealed the oxytocin (OT) and its receptor (OTR) have a relationship with MI and sympathetic system. It is assumed that OT has an close relationship with superior cervical ganglion (SCG), but the existence of oxytocin receptors in SCG has not been well clarified. OBJECTIVE:Our research aims to explore the expression of OTR in SCG in the setting of MI. METHODS AND RESULTS:MI was induced by coronary artery ligation. Rats were randomly assigned to 2 groups: control, MI. The expression of OTR was measured by Western blotting. Distribution of OTR in SCG was investigated by immunofluorescence. Retrograde tracing test revealed the sprouting of tyrosine hydroxylase (TH: the marker

SUBMITTER: Yu R 

PROVIDER: S-EPMC6958027 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature