Effect of the conditional knockout of bone marrow specific RIPK3 gene on bone marrow hematopoiesis in mice.

ABSTRACT: Receptor-interacting serine-threonine kinase 3 (RIPk3) is a key signaling molecule in the regulation of cell apoptosis and necroptosis, it plays an important role in the pathophysiological changes of many hematologic diseases. However, the regulatory role of RIPk3 in programmed cell death (PCD) is not fully known. In this study, bone marrow-specific RIPk3 gene knockout homozygotes (RIPk3-/- mice) were established by homologous recombination. The physiological index of peripheral blood, the morphology and structure of the bone marrow, the bone marrow nucleated cells (BMNCs), the hemopoietic stem cells (HSCs), interleukin-6 (IL-6) level and the colony formation capacity of bone marrow hematopoietic progenitor cells were compared between RIPk3-/- mice and wild-type mice. The results showed th

SUBMITTER: Chen Y 

PROVIDER: S-EPMC6958049 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature